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Target
Reverse transcriptase
Ligand
BDBM50478157
Substrate
n/a
Meas. Tech.
ChEMBL_721311 (CHEMBL1675423)
Kd
4000±n/a nM
Citation
 Sluis-Cremer, N; Koontz, D; Bassit, L; Hernandez-Santiago, BI; Detorio, M; Rapp, KL; Amblard, F; Bondada, L; Grier, J; Coats, SJ; Schinazi, RF; Mellors, JW Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides. Antimicrob Agents Chemother 53:3715-9 (2009) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50478157
Synonyms:
Carbovir-Triphosphate
Type:
Small organic molecule
Emp. Form.:
C11H18N5O11P3
Mol. Mass.:
489.2088
SMILES:
Nc1nc2N(CNc2c(=O)[nH]1)[C@@H]1C[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=C1 |r,c:30|
Structure:
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