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Target
Peptidylglycine alpha-amidating monooxygenase
Ligand
BDBM50030363
Substrate
n/a
Meas. Tech.
ChEMBL_154488 (CHEMBL765265)
IC50
18±n/a nM
Citation
 Erion, MD; Tan, J; Wong, M; Jeng, AY Inhibition of peptidylglycine alpha-amidating monooxygenase by N-substituted homocysteine analogs. J Med Chem 37:4430-7 (1995) [PubMed]
Target
Name:
Peptidylglycine alpha-amidating monooxygenase
Synonyms:
AMD_RAT | Pam | Peptidyl-glycine alpha-amidating monooxygenase
Type:
PROTEIN
Mol. Mass.:
108665.78
Organism:
Rattus norvegicus
Description:
ChEMBL_536304
Residue:
976
Sequence:
MAGRARSGLLLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTIGPVTPLDASDFALDIRMPGVTPKESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSVHLTRVPQPLIAGMYLMMSVDTVIPPGEKVVNADISCQYKMYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQNPQLPQAFYPVEHPVDVTFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEANIPIPVKPDMVMMHGHHKEAENKEKSALMQQPKQGEEEVLEQGDFYSLLSKLLGEREDVHVHKYNPTEKTESGSDLVAEIANVVQKKDLGRSDAREGAEHEEWGNAILVRDRIHRFHQLESTLRPAESRAFSFQQPGEGPWEPEPSGDFHVEEELDWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSKFVYQQRGLGPIEEDTILVIDPNNAEILQSSGKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLDPHSKEGPLLILGRSMQPGSDQNHFCQPTDVAVEPSTGAVFVSDGYCNSRIVQFSPSGKFVTQWGEESSGSSPRPGQFSVPHSLALVPHLDQLCVADRENGRIQCFKTDTKEFVREIKHASFGRNVFAISYIPGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKMEHRSVKKAGIEVQEIKEAEAVVEPKVENKPTSSELQKMQEKQKLSTEPGSGVSVVLITTLLVIPVLVLLAIVMFIRWKKSRAFGDHDRKLESSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRVSTEGSDQEKDEDDGTESEEEYSAPLPKPAPSS
  
Inhibitor
Name:
BDBM50030363
Synonyms:
(S)-2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-4-mercapto-butyric acid | CHEMBL277080
Type:
Small organic molecule
Emp. Form.:
C21H24N2O5S
Mol. Mass.:
416.491
SMILES:
OC(=O)[C@H](CCS)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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