Reaction Details  Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50030545
Substrate
n/a
Meas. Tech.
ChEMBL_195358 (CHEMBL802598)
IC50
50200±n/a nM
Citation
 Maruenda, H; Johnson, F Design and synthesis of novel inhibitors of HIV-1 reverse transcriptase. J Med Chem 38:2145-51 (1995) [PubMed]
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50030545
Synonyms:
4-Ethoxymethyl-10,11-dihydro-4H-5-thia-2,4,10-triaza-dibenzo[a,d]cycloheptene-1,3-dione | CHEMBL302788
Type:
Small organic molecule
Emp. Form.:
C14H15N3O3S
Mol. Mass.:
305.352
SMILES:
CCOCn1c2Sc3ccccc3NCc2c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: