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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50032432
Substrate
n/a
Meas. Tech.
ChEMBL_159318 (CHEMBL769371)
IC50
12±n/a nM
Citation
 Wang, GT; Li, S; Wideburg, N; Krafft, GA; Kempf, DJ Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores. J Med Chem 38:2995-3002 (1995) [PubMed]
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50032432
Synonyms:
(S)-2-[2-(2-Amino-thiazol-4-yl)-acetylamino]-N-((1S,2R,3R,4S)-4-{(S)-2-[2-(2-amino-thiazol-4-yl)-acetylamino]-3-methyl-butyrylamino}-1-benzyl-2,3-dihydroxy-5-phenyl-pentyl)-3-methyl-butyramide | CHEMBL321514
Type:
Small organic molecule
Emp. Form.:
C38H50N8O6S2
Mol. Mass.:
778.984
SMILES:
CC(C)[C@H](NC(=O)Cc1csc(N)n1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)Cc1csc(N)n1)C(C)C
Structure:
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