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Target
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Ligand
BDBM50488585
Substrate
n/a
Meas. Tech.
ChEMBL_925415 (CHEMBL3072453)
IC50
>2300000±n/a nM
Citation
 He, HW; Peng, H; Wang, T; Wang, C; Yuan, JL; Chen, T; He, J; Tan, X ?-(Substituted-phenoxyacetoxy)-?-heterocyclylmethylphosphonates: synthesis, herbicidal activity, inhibition on pyruvate dehydrogenase complex (PDHc), and application as postemergent herbicide against broadleaf weeds. J Agric Food Chem 61:2479-88 (2013) [PubMed]  Article
Target
Name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Synonyms:
1.2.4.1 | ODPB_PEA | PDHE1-B | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Type:
PROTEIN
Mol. Mass.:
38791.52
Organism:
Pisum sativum
Description:
ChEMBL_106715
Residue:
359
Sequence:
MLGVIRNKTIRPSFSAFRFFSSAKQMTVRDALNSALDVEMSADSKVFLMGEEVGEYQGAYKVTKGLLEKYGPERVLDTPITEAGFTGIGVGAAYYGLKPVVEFMTFNFSMQAIDHIINSAAKSNYMSAGQISVPIVFRGLNGDAAGVGAQHSHCYASWYGSCPGLKVLVPHSAEDARGLLKAAIRDPDPVVFLENELLYGESFPVSAEVLDSSFWLPIGKAKIEREGKDVTITAFSKMVGFALKAAEILEKEGISAEVINLRSIRPLDRPTINASVRKTNRLVTVEEGFPQHGVGAEICTSVIEESFGYLDATVERIGGADVPMPYAGNLERLVVPHVEDIVRAAKRACHRSVPLAAAA
  
Inhibitor
Name:
BDBM50488585
Synonyms:
CHEMBL2289465
Type:
Small organic molecule
Emp. Form.:
C17H17F3NO6P
Mol. Mass.:
419.289
SMILES:
COP(=O)(OC)C(OC(=O)COc1cccc(c1)C(F)(F)F)c1ccccn1
Structure:
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