Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50034116
Substrate
n/a
Meas. Tech.
ChEMBL_143852 (CHEMBL747209)
IC50
12±n/a nM
Citation
 Leban, JJ; Heyer, D; Landavazo, A; Matthews, J; Aulabaugh, A; Daniels, AJ Novel modified carboxy terminal fragments of neuropeptide Y with high affinity for Y2-type receptors and potent functional antagonism at a Y1-type receptor. J Med Chem 38:1150-7 (1995) [PubMed]
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY2R | Neuropeptide Y receptor type 2 | Neuropeptide Y/peptide YY-Y2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42514.44
Organism:
RAT
Description:
NPY-Y2 NPY2R RAT::Q9ERC0
Residue:
381
Sequence:
MGPLGAEADENQTVEVKVELYGSGPTTPRGELPPDPEPELIDSTKLVEVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMTFKAKKNLEVKKNNGLTDSFSEATNV
  
Inhibitor
Name:
BDBM50034116
Synonyms:
Arg-His-Tyr-Ile-Asn-Leu-Ile-Tyr-Arg-Leu-Arg-Tyr-NH2 | CHEMBL383861
Type:
Small organic molecule
Emp. Form.:
C79H123N25O16
Mol. Mass.:
1678.9798
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Structure:
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