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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50489465
Substrate
n/a
Meas. Tech.
ChEMBL_938263 (CHEMBL2328686)
Ki
71000±n/a nM
Citation
 Horlacher, OP; Hartkoorn, RC; Cole, ST; Altmann, KH Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins. ACS Med Chem Lett 4:264-8 (2013) [PubMed]  Article
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM50489465
Synonyms:
CHEMBL2323583
Type:
Small organic molecule
Emp. Form.:
C26H32N4O8
Mol. Mass.:
528.5543
SMILES:
CC(C)[C@H]1OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O |r|
Structure:
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