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Target
Reverse transcriptase
Ligand
BDBM50490646
Substrate
n/a
Meas. Tech.
ChEMBL_949008 (CHEMBL2342760)
Ki
1000±n/a nM
Citation
 Novikov, MS; Valuev-Elliston, VT; Babkov, DA; Paramonova, MP; Ivanov, AV; Gavryushov, SA; Khandazhinskaya, AL; Kochetkov, SN; Pannecouque, C; Andrei, G; Snoeck, R; Balzarini, J; Seley-Radtke, KL N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem 21:1150-8 (2013) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50490646
Synonyms:
CHEMBL2337190
Type:
Small organic molecule
Emp. Form.:
C24H22N2O3
Mol. Mass.:
386.4431
SMILES:
Cc1ccc(OCCn2c3ccccc3c(=O)n(Cc3ccccc3)c2=O)cc1
Structure:
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