Reaction Details  Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50490702
Substrate
n/a
Meas. Tech.
ChEMBL_948640 (CHEMBL2345156)
IC50
0.346737±n/a nM
Citation
 Agelis, G; Resvani, A; Koukoulitsa, C; T?mová, T; Slaninová, J; Kalavrizioti, D; Spyridaki, K; Afantitis, A; Melagraki, G; Siafaka, A; Gkini, E; Megariotis, G; Grdadolnik, SG; Papadopoulos, MG; Vlahakos, D; Maragoudakis, M; Liapakis, G; Mavromoustakos, T; Matsoukas, J Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem 62:352-70 (2013) [PubMed]  Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50490702
Synonyms:
CHEMBL2337686
Type:
Small organic molecule
Emp. Form.:
C35H33BrN10
Mol. Mass.:
673.608
SMILES:
[Br-].CCCCc1c[n+](Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)cn1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Structure:
Search PDB for entries with ligand similarity: