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Target
Procathepsin L
Ligand
BDBM50491151
Substrate
n/a
Meas. Tech.
ChEMBL_957451 (CHEMBL2378147)
IC50
>10000±n/a nM
Citation
 Song, J; Jones, LM; Chavarria, GE; Charlton-Sevcik, AK; Jantz, A; Johansen, A; Bayeh, L; Soeung, V; Snyder, LK; Lade, SD; Chaplin, DJ; Trawick, ML; Pinney, KG Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Bioorg Med Chem Lett 23:2801-7 (2013) [PubMed]  Article
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50491151
Synonyms:
CHEMBL2376009
Type:
Small organic molecule
Emp. Form.:
C14H9N5O4S
Mol. Mass.:
343.317
SMILES:
[#7]-[#6](=S)-[#7]\[#7]=[#6]-1\c2cc(ccc2-c2ccc(cc-12)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O
Structure:
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