Reaction Details
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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM1039
Substrate
n/a
Meas. Tech.
ChEMBL_159454 (CHEMBL766799)
IC50
0.17±n/a nM
Citation
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More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM1039
Synonyms:
CHEMBL297620 | Hydroxyethylene dipeptide isostere 31 | tert-butyl N-[(2S,3S,5R)-5-[(4-tert-butylphenyl)methyl]-3-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}-1-phenylpentan-2-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C37H48N2O5
Mol. Mass.:
600.7874
SMILES:
[H][C@@]1(NC(=O)[C@@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)Cc2ccc(cc2)C(C)(C)C)[C@H](O)Cc2ccccc12 |r|