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Target
Procathepsin L
Ligand
BDBM50491478
Substrate
n/a
Meas. Tech.
ChEMBL_958841 (CHEMBL2384629)
IC50
39310±n/a nM
Citation
 Kim, SH; Lee, E; Baek, KH; Kwon, HB; Woo, H; Lee, ES; Kwon, Y; Na, Y Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorg Med Chem Lett 23:3320-4 (2013) [PubMed]  Article
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50491478
Synonyms:
CHEMBL2382113
Type:
Small organic molecule
Emp. Form.:
C18H17NO4
Mol. Mass.:
311.3319
SMILES:
COc1cc(O)ccc1\C=C\C(=O)c1ccc(NC(C)=O)cc1
Structure:
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