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Target
Cathepsin B
Ligand
BDBM50491478
Substrate
n/a
Meas. Tech.
ChEMBL_958842 (CHEMBL2384630)
IC50
46810±n/a nM
Citation
 Kim, SH; Lee, E; Baek, KH; Kwon, HB; Woo, H; Lee, ES; Kwon, Y; Na, Y Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorg Med Chem Lett 23:3320-4 (2013) [PubMed]  Article
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50491478
Synonyms:
CHEMBL2382113
Type:
Small organic molecule
Emp. Form.:
C18H17NO4
Mol. Mass.:
311.3319
SMILES:
COc1cc(O)ccc1\C=C\C(=O)c1ccc(NC(C)=O)cc1
Structure:
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