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Target
Histone deacetylase 8
Ligand
BDBM50491822
Substrate
n/a
Meas. Tech.
ChEMBL_963147 (CHEMBL2390789)
IC50
2599±n/a nM
Citation
 Guerrant, W; Patil, V; Canzoneri, JC; Yao, LP; Hood, R; Oyelere, AK Dual-acting histone deacetylase-topoisomerase I inhibitors. Bioorg Med Chem Lett 23:3283-7 (2013) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50491822
Synonyms:
CHEMBL2386909
Type:
Small organic molecule
Emp. Form.:
C33H38N6O7
Mol. Mass.:
630.6908
SMILES:
CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCc3cn(CCCCCCCC(=O)NO)nn3)cc12 |r|
Structure:
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