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Target
Thromboxane A2 receptor
Ligand
BDBM50037726
Substrate
n/a
Meas. Tech.
ChEMBL_209593 (CHEMBL814728)
IC50
30±n/a nM
Citation
 Cozzi, P; Giordani, A; Menichincheri, M; Pillan, A; Pinciroli, V; Rossi, A; Tonani, R; Volpi, D; Tamburin, M; Ferrario, R Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids. J Med Chem 37:3588-604 (1994) [PubMed]
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50037726
Synonyms:
5-[1-Cyclohexyl-3-(3-fluoro-phenyl)-2-imidazol-1-yl-prop-(E)-ylideneaminooxy]-pentanoic acid | CHEMBL333237
Type:
Small organic molecule
Emp. Form.:
C23H30FN3O3
Mol. Mass.:
415.501
SMILES:
OC(=O)CCCCO\N=C(\C(Cc1cccc(F)c1)n1ccnc1)C1CCCCC1
Structure:
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