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Target
Reverse transcriptase
Ligand
BDBM50492504
Substrate
n/a
Meas. Tech.
ChEMBL_972305 (CHEMBL2411981)
IC50
16600±n/a nM
Citation
 Billamboz, M; Suchaud, V; Bailly, F; Lion, C; Demeulemeester, J; Calmels, C; Andréola, ML; Christ, F; Debyser, Z; Cotelle, P 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. ACS Med Chem Lett 4:606-11 (2013) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50492504
Synonyms:
CHEMBL2407277
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O5
Mol. Mass.:
360.749
SMILES:
COc1ccc(NC(=O)C2C(=O)N(O)C(=O)c3ccccc23)cc1Cl
Structure:
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