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Target
Carbonic anhydrase 12
Ligand
BDBM50492882
Substrate
n/a
Meas. Tech.
ChEMBL_975901 (CHEMBL2415550)
Ki
3.4±n/a nM
Citation
 Leitans, J; Sprudza, A; Tanc, M; Vozny, I; Zalubovskis, R; Tars, K; Supuran, CT 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies. Bioorg Med Chem 21:5130-8 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50492882
Synonyms:
CHEMBL2414075
Type:
Small organic molecule
Emp. Form.:
C13H11FN4O4S3
Mol. Mass.:
402.444
SMILES:
CS(=O)(=O)c1ccc(c(F)c1)-n1cc(nn1)-c1ccc(s1)S(N)(=O)=O
Structure:
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