Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50492880
Substrate
n/a
Meas. Tech.
ChEMBL_975904 (CHEMBL2415553)
Ki
3.0±n/a nM
Citation
 Leitans, J; Sprudza, A; Tanc, M; Vozny, I; Zalubovskis, R; Tars, K; Supuran, CT 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies. Bioorg Med Chem 21:5130-8 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50492880
Synonyms:
CHEMBL2414072
Type:
Small organic molecule
Emp. Form.:
C12H8ClFN4O2S2
Mol. Mass.:
358.799
SMILES:
NS(=O)(=O)c1ccc(s1)-c1cn(nn1)-c1ccc(F)c(Cl)c1
Structure:
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