Reaction Details  Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50493222
Substrate
n/a
Meas. Tech.
ChEMBL_979078 (CHEMBL2421337)
IC50
27±n/a nM
Citation
 Park, HR; Kim, J; Kim, T; Jo, S; Yeom, M; Moon, B; Choo, IH; Lee, J; Lim, EJ; Park, KD; Min, SJ; Nam, G; Keum, G; Lee, CJ; Choo, H Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease. Bioorg Med Chem 21:5480-7 (2013) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50493222
Synonyms:
CHEMBL2418211
Type:
Small organic molecule
Emp. Form.:
C17H16FN3S
Mol. Mass.:
313.392
SMILES:
Fc1ccc(cc1)-c1nc2ccc(nc2s1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: