Reaction Details  Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50039348
Substrate
n/a
Meas. Tech.
ChEMBL_36643 (CHEMBL652353)
Ki
41±n/a nM
Citation
 Nicolaï, E; Curé, G; Goyard, J; Kirchner, M; Teulon, JM; Versigny, A; Cazes, M; Caussade, F; Virone-Oddos, A; Cloarec, A Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists. J Med Chem 37:2371-86 (1994) [PubMed]
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50039348
Synonyms:
2-[4-(5-Methyl-3-oxo-7-propyl-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-8-ylmethyl)-phenylcarbamoyl]-benzenesulfonic acid | CHEMBL80167
Type:
Small organic molecule
Emp. Form.:
C23H23N5O5S
Mol. Mass.:
481.524
SMILES:
CCCc1nc(C)n2c(n[nH]c2=O)c1Cc1ccc(NC(=O)c2ccccc2S(O)(=O)=O)cc1
Structure:
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