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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50039361
Substrate
n/a
Meas. Tech.
ChEMBL_36643 (CHEMBL652353)
Ki
53±n/a nM
Citation
 Nicolaï, E; Curé, G; Goyard, J; Kirchner, M; Teulon, JM; Versigny, A; Cazes, M; Caussade, F; Virone-Oddos, A; Cloarec, A Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists. J Med Chem 37:2371-86 (1994) [PubMed]
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50039361
Synonyms:
2,5-Dimethyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-[1,2,4]triazolo[4,3-c]pyrimidin-3-one | CHEMBL76421
Type:
Small organic molecule
Emp. Form.:
C24H24N8O
Mol. Mass.:
440.5004
SMILES:
CCCc1nc(C)n2c(nn(C)c2=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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