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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50493698
Substrate
n/a
Meas. Tech.
ChEMBL_987752 (CHEMBL2439843)
EC50
240±n/a nM
Citation
 Huynh, T; Valant, C; Crosby, IT; Sexton, PM; Christopoulos, A; Capuano, B Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor. J Med Chem 56:8196-200 (2013) [PubMed]  Article
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50493698
Synonyms:
CHEMBL2435362
Type:
Small organic molecule
Emp. Form.:
C18H18ClF2N3O2S
Mol. Mass.:
413.869
SMILES:
Cl.COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)c(F)c1F
Structure:
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