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Target
Carbonic anhydrase 12
Ligand
BDBM11053
Substrate
n/a
Meas. Tech.
ChEMBL_992705 (CHEMBL2443607)
Ki
6.4±n/a nM
Citation
 Güzel-Akdemir, O; Biswas, S; Lastra, K; McKenna, R; Supuran, CT Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorg Med Chem 21:6674-80 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM11053
Synonyms:
CHEMBL386049 | N-(4-sulfamoylphenyl)-2-sulfanylbenzamide | reduced monomeric thio of compound 5a | reduced thio H5a
Type:
Small organic molecule
Emp. Form.:
C13H12N2O3S2
Mol. Mass.:
308.376
SMILES:
NS(=O)(=O)c1ccc(NC(=O)c2ccccc2S)cc1
Structure:
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