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Target
Integrase
Ligand
BDBM50493934
Substrate
n/a
Meas. Tech.
ChEMBL_989139 (CHEMBL2446202)
IC50
1400±n/a nM
Citation
 Sharma, H; Sanchez, TW; Neamati, N; Detorio, M; Schinazi, RF; Cheng, X; Buolamwini, JK Synthesis, docking, and biological studies of phenanthrene ?-diketo acids as novel HIV-1 integrase inhibitors. Bioorg Med Chem Lett 23:6146-51 (2013) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50493934
Synonyms:
CHEMBL2442281
Type:
Small organic molecule
Emp. Form.:
C18H11ClO4
Mol. Mass.:
326.731
SMILES:
OC(=O)C(=O)CC(=O)c1ccc2c(ccc3cc(Cl)ccc23)c1
Structure:
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