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Target
Histamine H3 receptor
Ligand
BDBM50494141
Substrate
n/a
Meas. Tech.
ChEMBL_990483 (CHEMBL2446560)
IC50
7.9±n/a nM
Citation
 Harusawa, S; Sawada, K; Magata, T; Yoneyama, H; Araki, L; Usami, Y; Hatano, K; Yamamoto, K; Yamamoto, D; Yamatodani, A Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: high affinity and human/rat species-selective histamine H(3) receptor antagonists. Bioorg Med Chem Lett 23:6415-20 (2013) [PubMed]  Article
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50494141
Synonyms:
CHEMBL2441940
Type:
Small organic molecule
Emp. Form.:
C17H27Cl2N3S
Mol. Mass.:
376.387
SMILES:
Cl.Clc1ccc(CCNC(=N)SCCCN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: