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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50248859
Substrate
n/a
Meas. Tech.
ChEMBL_1275453 (CHEMBL3090387)
IC50
95±n/a nM
Citation
 Baur, B; Storch, K; Martz, KE; Goettert, MI; Richters, A; Rauh, D; Laufer, SA Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood. J Med Chem 56:8561-78 (2013) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50248859
Synonyms:
2-(2,4-Difluoro-phenylamino)-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one | CHEMBL515407
Type:
Small organic molecule
Emp. Form.:
C21H15F2NO
Mol. Mass.:
335.3467
SMILES:
Fc1ccc(Nc2ccc3c(CCc4ccccc4C3=O)c2)c(F)c1
Structure:
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