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Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM50494319
Substrate
n/a
Meas. Tech.
ChEMBL_1276212 (CHEMBL3089535)
EC50
>50000±n/a nM
Citation
 Guerrero, M; Poddutoori, R; Urbano, M; Peng, X; Spicer, TP; Chase, PS; Hodder, PS; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorg Med Chem Lett 23:6346-9 (2013) [PubMed]  Article
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM50494319
Synonyms:
CHEMBL1969371
Type:
Small organic molecule
Emp. Form.:
C21H32N2O2
Mol. Mass.:
344.491
SMILES:
CC1CCCCC1N(C1CCCCC1C)C(=O)c1cc(on1)C1CC1
Structure:
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