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Target
Carbonic anhydrase 7
Ligand
BDBM50341581
Substrate
n/a
Meas. Tech.
ChEMBL_1281628 (CHEMBL3102438)
Ki
5.4±n/a nM
Citation
 De Luca, L; Ferro, S; Damiano, FM; Supuran, CT; Vullo, D; Chimirri, A; Gitto, R Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors. Eur J Med Chem 71:105-11 (2014) [PubMed]  Article
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50341581
Synonyms:
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamide | 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide | CHEMBL1089044
Type:
Small organic molecule
Emp. Form.:
C11H16N2O4S
Mol. Mass.:
272.321
SMILES:
COc1cc2CCN(Cc2cc1OC)S(N)(=O)=O
Structure:
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