Reaction Details  Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50041932
Substrate
n/a
Meas. Tech.
ChEBML_55135
IC50
3900±n/a nM
Citation
 Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem 36:3103-12 (1993) [PubMed]
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50041932
Synonyms:
5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL323155
Type:
Small organic molecule
Emp. Form.:
C10H12N4S
Mol. Mass.:
220.294
SMILES:
Nc1nc(N)c2c3CCCCc3sc2n1
Structure:
Search PDB for entries with ligand similarity: