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Target
Dihydrofolate reductase
Ligand
BDBM50029769
Substrate
n/a
Meas. Tech.
ChEBML_55135
IC50
5900±n/a nM
Citation
 Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem 36:3103-12 (1993) [PubMed]
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50029769
Synonyms:
6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL322585
Type:
Small organic molecule
Emp. Form.:
C17H20N4O2S
Mol. Mass.:
344.431
SMILES:
COc1ccc(OC)c(CCc2sc3nc(N)nc(N)c3c2C)c1
Structure:
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