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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50042076
Substrate
n/a
Meas. Tech.
ChEBML_28188
IC50
56±n/a nM
Citation
 Trivedi, BK; Holmes, A; Stoeber, TL; Blankley, CJ; Roark, WH; Picard, JA; Shaw, MK; Essenburg, AD; Stanfield, RL; Krause, BR Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents. J Med Chem 36:3300-7 (1993) [PubMed]
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50042076
Synonyms:
1-(2,6-Diethyl-phenyl)-3-(1-phenyl-cyclopentylmethyl)-urea | CHEMBL325384
Type:
Small organic molecule
Emp. Form.:
C23H30N2O
Mol. Mass.:
350.4971
SMILES:
CCc1cccc(CC)c1NC(=O)NCC1(CCCC1)c1ccccc1
Structure:
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