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Target
Carbonic anhydrase 1
Ligand
BDBM50495345
Substrate
n/a
Meas. Tech.
ChEMBL_1286431 (CHEMBL3112019)
Ki
72200±n/a nM
Citation
 Rodrigues, GC; Feijó, DF; Bozza, MT; Pan, P; Vullo, D; Parkkila, S; Supuran, CT; Capasso, C; Aguiar, AP; Vermelho, AB Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease. J Med Chem 57:298-308 (2014) [PubMed]  Article
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50495345
Synonyms:
CHEMBL3110149
Type:
Small organic molecule
Emp. Form.:
C12H14N2O4
Mol. Mass.:
250.2506
SMILES:
CCOc1ccccc1C1=NOC(C1)C(=O)NO |t:10|
Structure:
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