Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50496121
Substrate
n/a
Meas. Tech.
ChEMBL_1294037 (CHEMBL3122548)
Ki
178±n/a nM
Citation
 Sagnes, C; Fournet, G; Satala, G; Bojarski, AJ; Joseph, B New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies. Eur J Med Chem 75:159-68 (2014) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50496121
Synonyms:
CHEMBL3121412
Type:
Small organic molecule
Emp. Form.:
C31H30N2O4
Mol. Mass.:
494.5809
SMILES:
OC(=O)\C=C\C(O)=O.Cc1ccccc1-n1cc(CN2CCC(=CC2)c2ccccc2)c2ccccc12 |c:22|
Structure:
Search PDB for entries with ligand similarity: