Reaction Details  Report a problem with these data
Target
Lethal(3)malignant brain tumor-like protein 3
Ligand
BDBM50496590
Substrate
n/a
Meas. Tech.
ChEMBL_1300220 (CHEMBL3136684)
IC50
1000±n/a nM
Citation
 Camerino, MA; Zhong, N; Dong, A; Dickson, BM; James, LI; Baughman, BM; Norris, JL; Kireev, DB; Janzen, WP; Arrowsmith, CH; Frye, SV The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface. Medchemcomm 4:1501-1507 (2013) [PubMed]  Article
Target
Name:
Lethal(3)malignant brain tumor-like protein 3
Synonyms:
H-l(3)mbt-like protein 3 | KIAA1798 | L(3)mbt-like protein 3 | L3MBTL3 | LMBL3_HUMAN | Lethal(3)malignant brain tumor-like protein 3 | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) | MBT-1 | MBT1
Type:
Protein
Mol. Mass.:
88334.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
  
Inhibitor
Name:
BDBM50496590
Synonyms:
CHEMBL3134145
Type:
Small organic molecule
Emp. Form.:
C20H29F2N3
Mol. Mass.:
349.4612
SMILES:
FC1(F)CN(CCc2ccc(cc2)N2CCC(CC2)N2CCCC2)C1
Structure:
Search PDB for entries with ligand similarity: