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Target
D(2) dopamine receptor
Ligand
BDBM50047095
Substrate
n/a
Meas. Tech.
ChEMBL_58560 (CHEMBL667495)
IC50
4.6±n/a nM
Citation
 Malleron, JL; Guérémy, C; Mignani, S; Peyronel, JF; Truchon, A; Blanchard, JC; Doble, A; Laduron, P; Piot, O; Zundel, JL New indole derivatives as potent and selective serotonin uptake inhibitors. J Med Chem 36:1194-202 (1993) [PubMed]
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50047095
Synonyms:
2-{3-[4-(1H-Indol-3-yl)-piperidin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide | CHEMBL281808
Type:
Small organic molecule
Emp. Form.:
C26H27N3O2S
Mol. Mass.:
445.576
SMILES:
O=S1(=O)N(CCCN2CCC(CC2)c2c[nH]c3ccccc23)c2cccc3cccc1c23
Structure:
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