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Target
D(2) dopamine receptor
Ligand
BDBM50048804
Substrate
n/a
Meas. Tech.
ChEMBL_62860 (CHEMBL677675)
Ki
3.8±n/a nM
Citation
 Howard, HR; Lowe, JA; Seeger, TF; Seymour, PA; Zorn, SH; Maloney, PR; Ewing, FE; Newman, ME; Schmidt, AW; Furman, JS; Robinson, GL; Jackson, E; Johnson, C; Morrone, J 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 39:143-8 (1996) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50048804
Synonyms:
5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-1,3-dihydro-indol-2-one | CHEMBL35743
Type:
Small organic molecule
Emp. Form.:
C21H22N4OS
Mol. Mass.:
378.491
SMILES:
O=C1Cc2cc(CCN3CCN(CC3)c3nsc4ccccc34)ccc2N1
Structure:
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