Reaction Details Report a problem with these data
Target
Squalene synthase
Ligand
BDBM50049229
Substrate
n/a
Meas. Tech.
ChEMBL_202112 (CHEMBL808970)
IC50
192±n/a nM
Citation
Magnin, DR; Biller, SA; Chen, Y; Dickson, JK; Fryszman, OM; Lawrence, RM; Logan, JV; Sieber-McMaster, ES; Sulsky, RB; Traeger, SC; Hsieh, DC; Lan, SJ; Rinehart, JK; Harrity, TW; Jolibois, KG; Kunselman, LK; Rich, LC; Slusarchyk, DA; Ciosek, CP alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase. J Med Chem 39:657-60 (1996) [PubMed] Article
More Info.:
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
Inhibitor
Name:
BDBM50049229
Synonyms:
1-Phosphono-4-[4-(4-butylphenyl)phenyl]butylsulfonic Acid Tripotassium Salt | CHEMBL158844 | Tripotassium salt of 4-(4'-Butyl-biphenyl-4-yl)-1-phosphono-butane-1-sulfonic acid
Type:
Small organic molecule
Emp. Form.:
C20H24O6PS
Mol. Mass.:
423.441
SMILES:
CCCCc1ccc(cc1)-c1ccc(CCCC(P([O-])([O-])=O)S([O-])(=O)=O)cc1