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Target
Cholinesterase
Ligand
BDBM50500596
Substrate
n/a
Meas. Tech.
ChEMBL_1548298 (CHEMBL3755749)
IC50
58500±n/a nM
Citation
 Turan-Zitouni, G; Alt?ntop, MD; Özdemir, A; Kaplanc?kl?, ZA; Çiftçi, GA; Temel, HE Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents. Eur J Med Chem 107:288-94 (2016) [PubMed]  Article
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM50500596
Synonyms:
CHEMBL3752902
Type:
Small organic molecule
Emp. Form.:
C36H34N4O6S2
Mol. Mass.:
682.808
SMILES:
COc1ccc(OC)c(c1)-c1csc(Nc2ccc(cc2OC)-c2ccc(Nc3nc(cs3)-c3cc(OC)ccc3OC)c(OC)c2)n1
Structure:
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