Reaction Details  Report a problem with these data
Target
Neuromedin-U receptor 1
Ligand
BDBM50500782
Substrate
n/a
Meas. Tech.
ChEMBL_1550246 (CHEMBL3760529)
EC50
59±n/a nM
Citation
 Micewicz, ED; Bahattab, OS; Willars, GB; Waring, AJ; Navab, M; Whitelegge, JP; McBride, WH; Ruchala, P Small lipidated anti-obesity compounds derived from neuromedin U. Eur J Med Chem 101:616-26 (2015) [PubMed]  Article
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | GPR66 | NMU-R1 | NMUR1 | NMUR1_HUMAN | Neuromedin-U receptor 1
Type:
PROTEIN
Mol. Mass.:
47370.42
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103121
Residue:
426
Sequence:
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
  
Inhibitor
Name:
BDBM50500782
Synonyms:
CHEMBL3758687
Type:
Small organic molecule
Emp. Form.:
C53H83N17O10
Mol. Mass.:
1118.334
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NC(C)(C)C(N)=O |r|
Structure:
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