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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051442
Substrate
n/a
Meas. Tech.
ChEMBL_28798 (CHEMBL641708)
IC50
>5000±n/a nM
Citation
 O'Brien, PM; Sliskovic, DR; Picard, JA; Lee, HT; Purchase, CF; Roth, BD; White, AD; Anderson, M; Mueller, SB; Bocan, T; Bousley, R; Hamelehle, KL; Homan, R; Lee, P; Krause, BR; Reindel, JF; Stanfield, RL; Turluck, D Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. J Med Chem 39:2354-66 (1996) [PubMed]  Article
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50051442
Synonyms:
2-Cyano-N-(2,6-diisopropyl-phenyl)-2-(2-dodecyl-2H-tetrazol-5-yl)-acetamide | CHEMBL76425
Type:
Small organic molecule
Emp. Form.:
C28H44N6O
Mol. Mass.:
480.6886
SMILES:
CCCCCCCCCCCCn1nnc(n1)C(C#N)C(=O)Nc1c(cccc1C(C)C)C(C)C
Structure:
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