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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50502852
Substrate
n/a
Meas. Tech.
ChEMBL_1809065 (CHEMBL4308424)
IC50
5780±n/a nM
Citation
 Liao, Y; Jia, X; Tang, Y; Li, S; Zang, Y; Wang, L; Cui, ZN; Song, G Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50502852
Synonyms:
CHEMBL4464755
Type:
Small organic molecule
Emp. Form.:
C29H30N2O4
Mol. Mass.:
470.5595
SMILES:
COc1ccccc1NC(=O)C1Cc2cc(OC3CCCC3)c(OC)cc2C(=N1)c1ccccc1 |c:30|
Structure:
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