Reaction Details  Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50053357
Substrate
n/a
Meas. Tech.
ChEMBL_46830 (CHEMBL875683)
Ki
0.73±n/a nM
Citation
 Huffman, JW; Yu, S; Showalter, V; Abood, ME; Wiley, JL; Compton, DR; Martin, BR; Bramblett, RD; Reggio, PH Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. J Med Chem 39:3875-7 (1996) [PubMed]  Article
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50053357
Synonyms:
(6aR,10aR)-9-Hydroxymethyl-6,6-dimethyl-3-nonyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | CHEMBL338484
Type:
Small organic molecule
Emp. Form.:
C25H38O3
Mol. Mass.:
386.5674
SMILES:
CCCCCCCCCc1cc(O)c2[C@@H]3CC(CO)=CC[C@H]3C(C)(C)Oc2c1 |c:18|
Structure:
Search PDB for entries with ligand similarity: