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Target
Histone deacetylase 8
Ligand
BDBM50503690
Substrate
n/a
Meas. Tech.
ChEMBL_1811453 (CHEMBL4310913)
IC50
9100±n/a nM
Citation
 Luckhurst, CA; Aziz, O; Beaumont, V; Bürli, RW; Breccia, P; Maillard, MC; Haughan, AF; Lamers, M; Leonard, P; Matthews, KL; Raphy, G; Stott, AJ; Munoz-Sanjuan, I; Thomas, B; Wall, M; Wishart, G; Yates, D; Dominguez, C Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg Med Chem Lett 29:83-88 (2019) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50503690
Synonyms:
CHEMBL4456445
Type:
Small organic molecule
Emp. Form.:
C19H13F4N3O2
Mol. Mass.:
391.319
SMILES:
ONC(=O)C(c1ccc(cc1)-c1ncc(cn1)C(F)(F)F)c1ccccc1F
Structure:
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