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Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50504057
Substrate
n/a
Meas. Tech.
ChEMBL_1813255 (CHEMBL4312829)
IC50
>500000±n/a nM
Citation
 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F Mechanistic Insight on the Mode of Action of Colletoic Acid. J Med Chem 62:6925-6940 (2019) [PubMed]  Article
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM50504057
Synonyms:
CHEMBL4531837
Type:
Small organic molecule
Emp. Form.:
C16H26O3
Mol. Mass.:
266.3758
SMILES:
COC(=O)[C@H]1CC[C@@H](C(C)C)[C@@]11CC=C(C)[C@@H](O)C1 |r,t:14|
Structure:
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