Reaction Details  Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50504454
Substrate
n/a
Meas. Tech.
ChEMBL_1814818 (CHEMBL4314392)
IC50
340±n/a nM
Citation
 Huang, Y; Wei, L; Han, X; Chen, H; Ren, Y; Xu, Y; Song, R; Rao, L; Su, C; Peng, C; Feng, L; Wan, J Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects. Eur J Med Chem 184:0 (2019) [PubMed]  Article
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50504454
Synonyms:
CHEMBL4593275
Type:
Small organic molecule
Emp. Form.:
C9H6N2O2
Mol. Mass.:
174.1561
SMILES:
[O-][N+](=O)\C=C\c1ccc(cc1)C#N
Structure:
Search PDB for entries with ligand similarity: