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Target
Kallikrein-5
Ligand
BDBM50505097
Substrate
n/a
Meas. Tech.
ChEMBL_1821332 (CHEMBL4320992)
IC50
14000±n/a nM
Citation
 de Souza, AS; Pacheco, BDC; Pinheiro, S; Muri, EMF; Dias, LRS; Lima, CHS; Garrett, R; de Moraes, MBM; de Souza, BEG; Puzer, L 3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7. Bioorg Med Chem Lett 29:1094-1098 (2019) [PubMed]  Article
Target
Name:
Kallikrein-5
Synonyms:
KLK5 | KLK5_HUMAN | Kallikrein 5 | SCTE | kallikrein-related peptidase 5 preproprotein
Type:
PROTEIN
Mol. Mass.:
32031.72
Organism:
Homo sapiens (Human)
Description:
EBI_12584
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM50505097
Synonyms:
CHEMBL4557443
Type:
Small organic molecule
Emp. Form.:
C34H49NO5
Mol. Mass.:
551.7566
SMILES:
CCCCC\C=C/C\C=C/CCCCCCC\C(O)=C1\C(=O)[C@H](Cc2ccccc2)N(C(=O)OC(C)(C)C)C1=O |r|
Structure:
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