Reaction Details 
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Spindlin-1
Ligand
BDBM50505585
Substrate
n/a
Meas. Tech.
ChEMBL_1823333 (CHEMBL4323097)
IC50
600±n/a nM
Citation
Fagan, V; Johansson, C; Gileadi, C; Monteiro, O; Dunford, JE; Nibhani, R; Philpott, M; Malzahn, J; Wells, G; Faram, R; Cribbs, AP; Halidi, N; Li, F; Chau, I; Greschik, H; Velupillai, S; Allali-Hassani, A; Bennett, J; Christott, T; Giroud, C; Lewis, AM; Huber, KVM; Athanasou, N; Bountra, C; Jung, M; Schüle, R; Vedadi, M; Arrowsmith, C; Xiong, Y; Jin, J; Fedorov, O; Farnie, G; Brennan, PE; Oppermann, U A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J Med Chem 62:9008-9025 (2019) [PubMed] ArticleMore Info.:
Target
Name:
Spindlin-1
Synonyms:
OCR | Ovarian cancer-related protein | SPIN | SPIN1 | SPIN1_HUMAN | Spindlin-1 | Spindlin1
Type:
PROTEIN
Mol. Mass.:
29602.24
Organism:
Homo sapiens
Description:
ChEMBL_119259
Residue:
262
Sequence:
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
Inhibitor
Name:
BDBM50505585
Synonyms:
CHEMBL4518756
Type:
Small organic molecule
Emp. Form.:
C25H31N3O3
Mol. Mass.:
421.5319
SMILES:
COc1ccc2CN(CCCOc3cc4N=C(N)C5(CCCC5)c4cc3OC)Cc2c1 |t:15|
Structure:
