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Target
Epidermal growth factor receptor
Ligand
BDBM50505838
Substrate
n/a
Meas. Tech.
ChEMBL_1824360 (CHEMBL4324124)
IC50
190±n/a nM
Citation
 Engelhardt, H; Böse, D; Petronczki, M; Scharn, D; Bader, G; Baum, A; Bergner, A; Chong, E; Döbel, S; Egger, G; Engelhardt, C; Ettmayer, P; Fuchs, JE; Gerstberger, T; Gonnella, N; Grimm, A; Grondal, E; Haddad, N; Hopfgartner, B; Kousek, R; Krawiec, M; Kriz, M; Lamarre, L; Leung, J; Mayer, M; Patel, ND; Simov, BP; Reeves, JT; Schnitzer, R; Schrenk, A; Sharps, B; Solca, F; Stadtmüller, H; Tan, Z; Wunberg, T; Zoephel, A; McConnell, DB Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors. J Med Chem 62:10272-10293 (2019) [PubMed]  Article
Target
Name:
Epidermal growth factor receptor
Synonyms:
EGFR_MOUSE | Egfr | Epidermal growth factor receptor erbB1
Type:
PROTEIN
Mol. Mass.:
134859.02
Organism:
Mus musculus
Description:
ChEMBL_305656
Residue:
1210
Sequence:
MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA
  
Inhibitor
Name:
BDBM50505838
Synonyms:
CHEMBL4537790
Type:
Small organic molecule
Emp. Form.:
C30H38N8O2
Mol. Mass.:
542.6751
SMILES:
C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1 |r,c:23|
Structure:
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