Reaction Details  Report a problem with these data
Target
Histone acetyltransferase type B catalytic subunit
Ligand
BDBM50506380
Substrate
n/a
Meas. Tech.
ChEMBL_1825678 (CHEMBL4325442)
IC50
>20000±n/a nM
Citation
 Yang, Y; Zhang, R; Li, Z; Mei, L; Wan, S; Ding, H; Chen, Z; Xing, J; Feng, H; Han, J; Jiang, H; Zheng, M; Luo, C; Zhou, B Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. J Med Chem 63:1337-1360 (2020) [PubMed]  Article
Target
Name:
Histone acetyltransferase type B catalytic subunit
Synonyms:
2.3.1.48 | HAT1 | HAT1_HUMAN | Histone acetyltransferase 1 | Histone acetyltransferase type B catalytic subunit | KAT1
Type:
PROTEIN
Mol. Mass.:
49505.96
Organism:
Homo sapiens
Description:
ChEMBL_118878
Residue:
419
Sequence:
MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE
  
Inhibitor
Name:
BDBM50506380
Synonyms:
CHEMBL4587968
Type:
Small organic molecule
Emp. Form.:
C27H23F4N5O4
Mol. Mass.:
557.4962
SMILES:
Cn1cc(cn1)-c1ccc2c(CC[C@]22NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: