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Target
Isocitrate dehydrogenase [NADP] cytoplasmic
Ligand
BDBM50506584
Substrate
n/a
Meas. Tech.
ChEMBL_1826419 (CHEMBL4326293)
IC50
270±n/a nM
Citation
 Jakob, CG; Upadhyay, AK; Donner, PL; Nicholl, E; Addo, SN; Qiu, W; Ling, C; Gopalakrishnan, SM; Torrent, M; Cepa, SP; Shanley, J; Shoemaker, AR; Sun, CC; Vasudevan, A; Woller, KR; Shotwell, JB; Shaw, B; Bian, Z; Hutti, JE Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem 61:6647-6657 (2018) [PubMed]  Article
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:
Protein
Mol. Mass.:
46661.29
Organism:
Homo sapiens (Human)
Description:
O75874
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM50506584
Synonyms:
CHEMBL221360
Type:
Small organic molecule
Emp. Form.:
C7H2Br4N2O
Mol. Mass.:
449.72
SMILES:
Brc1c(Br)c(Br)c2[nH]c(=O)[nH]c2c1Br
Structure:
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